Salvage therapy for primary CNS lymphoma with a combination of rituximab and temozolomide

被引：154
|
作者：
Enting, RH
Demopoulos, A
DeAngelis, LM
Abrey, LE
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Neurol, New York, NY 10021 USA
[2] Univ Groningen Hosp, Dept Neurol, Groningen, Netherlands
来源：
NEUROLOGY | 2004年 / 63卷 / 05期
关键词：
D O I：
10.1212/01.WNL.0000137050.43114.42
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The authors evaluated the efficacy of a combination of rituximab and temozolomide for recurrent or refractory primary CNS lymphoma (PCNSL). Fifteen patients with a median age of 69 years had a 53% objective response rate with acceptable toxicity. Median overall survival is 14 months and median progression free survival of responding patients is 7.7 months. This combination merits further study and provides a reasonable therapeutic alternative for older patients with progressive PCNSL.
引用
收藏
页码：901 / 903
页数：3
相关论文
共 50 条
  • [1] Salvage therapy for primary CNS lymphoma with a combination of rituximab and temozolomide
    Wong, ET
    NEUROLOGY, 2005, 64 (05) : 934 - 934
  • [2] Salvage therapy for primary CNS lymphoma with combination of rituximab and temozolomide
    Enting, RH
    Demopoulos, A
    DeAngelis, LM
    Abrey, LE
    NEUROLOGY, 2004, 62 (07) : A478 - A478
  • [3] Combination Therapy with Rituximab and Temozolomide for Recurrent and Refractory Primary Central Nervous System Lymphoma
    Murakami, Mineko
    Fujimaki, Takamitsu
    Asano, Shuichiro
    Nakaguchi, Hiroshi
    Yamada, Shoko M.
    Hoya, Katsumi
    Yamazaki, Kazuto
    Ishida, Yasuo
    Matsuno, Akira
    YONSEI MEDICAL JOURNAL, 2011, 52 (06) : 1031 - 1034
  • [4] Salvage therapy with temozolomide in an immunocompetent patient with primary brain lymphoma
    Reni, M
    Ferreri, AJM
    Landoni, C
    Villa, E
    JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (07) : 575 - 576
  • [5] SALVAGE IMMUNO-CHEMOTHERAPY WITH A COMBINATION OF RITUXIMAB AND HIGH-DOSE METHOTREXATE FOR PATIENTS WITH PRIMARY CNS LYMPHOMA
    Mishima, K.
    Suzuki, T.
    Adachi, J.
    Koga, T.
    Fukuoka, K.
    Yanagisawa, T.
    Fujimaki, T.
    Nishikawa, R.
    NEURO-ONCOLOGY, 2012, 14 : 84 - 84
  • [6] Primary CNS lymphoma in the elderly: temozolomide therapy and MGMT status
    Delia Kurzwelly
    Martin Glas
    Patrick Roth
    Elke Weimann
    Hanns Lohner
    Andreas Waha
    Martin Schabet
    Guido Reifenberger
    Michael Weller
    Ulrich Herrlinger
    Journal of Neuro-Oncology, 2010, 97 : 389 - 392
  • [7] Primary CNS lymphoma in the elderly: temozolomide therapy and MGMT status
    Kurzwelly, Delia
    Glas, Martin
    Roth, Patrick
    Weimann, Elke
    Lohner, Hanns
    Waha, Andreas
    Schabet, Martin
    Reifenberger, Guido
    Weller, Michael
    Herrlinger, Ulrich
    JOURNAL OF NEURO-ONCOLOGY, 2010, 97 (03) : 389 - 392
  • [8] Temozolomide for Relapsed Primary CNS Lymphoma
    Osmani, Asif Husain
    Masood, Nehal
    JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN, 2012, 22 (09): : 594 - 595
  • [9] Prospective trial on topotecan salvage therapy in primary CNS lymphoma
    Fischer, L.
    Thiel, E.
    Klasen, H. -A.
    Birkmann, J.
    Jahnke, K.
    Martus, P.
    Korfel, A.
    ANNALS OF ONCOLOGY, 2006, 17 (07) : 1141 - 1145
  • [10] Review of rituximab in primary CNS lymphoma
    Singh, Pawan K.
    Pan, Edward
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2020, 410
12345