Novel D-π-A type near-infrared fluorescent probes for the detection of Aβ40aggregates

被引：11
|
作者：
Lv, Guanglei [1 ,2 ]
Xu, Yunze [2 ]
Yang, Jiajia [2 ]
Li, Wenhui [1 ]
Li, Chunxia [2 ]
Sun, Anyang [1 ]
机构：
[1] Shanghai Univ Med & Hlth Sci, Shanghai Zhoupu Hosp, Dept Neurol, Shanghai 201318, Peoples R China
[2] Zhejiang Normal Univ, Minist Educ Adv Catalysis Mat, Key Lab, Jinhua 321004, Zhejiang, Peoples R China
来源：
ANALYST | 2020年 / 145卷 / 20期
基金：
中国国家自然科学基金;
关键词：
AMYLOID-BETA; ALZHEIMERS-DISEASE; AGGREGATION; PATHOLOGY; PEPTIDE; TAU;
D O I：
10.1039/d0an01180k
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Aberrant accumulation of Amyloid-beta (A beta) peptide is closely related to Alzheimer's disease. Thus, it is important to develop featured probes for the specific detection of A beta species. Herein, we designed and synthesized a novel near-infrared fluorescent probeSDPYbased on the D-pi-A architecture for the detection of A beta aggregates. The probeSDPYdisplayed higher affinity for A beta(40)aggregates over A beta(42)aggregates in solution (K-d= 164 nMvs.2.1 mu M). In addition,SDPYshowed excellent anti-interference against a wide range of other substances. Furthermore,SDPYwas capable of labeling A beta(40)aggregates better than A beta(42)aggregates in the brain sections of AD transgenic mouse models.
引用
收藏
页码：6579 / 6585
页数：7
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