Left heart abnormalities in connective tissue disease patients with pre-capillary pulmonary hypertension as well as borderline mean pulmonary arterial pressure

被引:1
|
作者
Tsuchida, Kosei [1 ]
Yamada, Hidehiro [1 ]
Yamasaki, Yoshioki [1 ]
Suzuki, Kengo [2 ]
Kongoji, Ken [2 ]
Akashi, Yoshihiro
Ozaki, Shoichi [1 ]
机构
[1] St Marianna Univ, Sch Med, Div Rheumatol & Allergol, Dept Internal Med,Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan
[2] St Marianna Univ, Sch Med, Div Cardiol, Dept Internal Med,Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan
关键词
Connective tissue disease; Borderline mPAP; Diastolic dysfunction; Left heart abnormalities; Pre-capillary pulmonary hypertension; SYSTEMIC-SCLEROSIS; ECHOCARDIOGRAPHY; DIAGNOSIS; EXERCISE; GRADIENT;
D O I
10.3109/14397595.2015.1005871
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To describe co-existence of left heart abnormalities among case series of connective tissue disease (CTD) patients who showed pre-capillary pulmonary hypertension (PH) as well as borderline mean pulmonary arterial pressure (mPAP). Methods. From 2010 through 2012, 49 CTD patients suspected to have PH by exercise Doppler echocardiography underwent right heart catheterization. We retrospectively searched for left heart diseases from the available data on Doppler echocardiography, cardiac magnetic resonance imaging (MRI), scintigraphy, and endomyocardial biopsy. Results. Among 49 patients, 11 and 2 had pre- and post-capillary PH, respectively, and another 10 had borderline mPAP. Six of 11 patients with pre-capillary PH showed low pulmonary vascular resistance (PVR) (<= 240 dynes.sec.cm(-5)) and low diastolic pulmonary gradient (< 7 mmHg). Seven of 10 patients with borderline mPAP had normal PVR (< 160) suggesting the presence of left heart abnormalities. Other abnormal findings included increased left atrial volume index and E/E'on Doppler echocardiography, delayed contrast enhancement by MRI, patchy area of hypoperfusion on thallium scintigraphy, and fibrosis in endomyocardial biopsy. Conclusion. The present case series suggested some contribution of left heart abnormalities to the increase in mPAP among CTD patients with pre-capillary PH as well as borderline mPAP.
引用
收藏
页码:744 / 747
页数:4
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