Simple antitumor model compounds for cross-conjugated cyclopentenone prostaglandins

被引：11

作者：

Vostrikov, Nikolay S. ^{[1
]}

Spirikhin, Leonid V. ^{[1
]}

Lobov, Alexander N. ^{[1
]}

Gimazetdinov, Airat M. ^{[1
]}

Zileeva, Zulfiya R. ^{[2
]}

Vakhitova, Yulia V. ^{[2
]}

Macaev, Zainutdin R. ^{[1
]}

Pivnitsky, Kashmir K. ^{[3
]}

Miftakhov, Mansur S. ^{[1
]}

机构：

[1] Russian Acad Sci, Ufa Inst Chem, Ufa 450054, Russia

[2] Russian Acad Sci, Inst Biochem & Genet, Ufa 450054, Russia

[3] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia

来源：

MENDELEEV COMMUNICATIONS | 2019年 / 29卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2); 15D-PGJ(2);

D O I：

10.1016/j.mencom.2019.07.003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Unstable methyl (5-methylidene-4-oxocyclopent-2-en-1-yl)acetate, having a ring moiety of J-type prostaglandins (PGJs) and similar cytotoxicity, reacts with EtSH and other thiols with formation of mono- and bis-adducts, which have been further converted by oxidation with mCPBA into corresponding stable mono-sulfones possessing cytotoxic effect most probably due to in vivo regeneration of the starting dienone. Thus, the derived sulfones can be used as transport forms for original dienone as a pharmacologically important moiety of Delta(12)-PGJ(2) and similar prostaglandins.

引用

页码：372 / 374

页数：3

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