Oxidative Copper-Catalyzed Regioselective Trifluoromethylation of Fused Imidazo[1,5-a]-N-heteroarenes using Langlois Reagent

被引：10
|
作者：
Sandeep, Mummadi [1 ,2 ]
Shantharjun, Bangarigalla [1 ,2 ]
Kumar, Geetala Pradeep [1 ,3 ]
Reddy, Kallu Rajender [1 ,2 ,3 ]
机构：
[1] Indian Inst Chem Technol, CSIR, Catalysis & Fine Chem Div, Hyderabad 500007, India
[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, UP, India
[3] IICT, CSIR, IICT RMIT Joint Res Ctr, Hyderabad 500007, India
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 2021卷 / 02期
关键词：
Copper; Homogeneous catalysis; Langlois reagent; Nitrogen heterocycles; Trifluoromethylation; C-H AMINATION; FLUORINE; ACCESS; CYCLIZATION; FORMAMIDES; 1,7-ENYNES; ACTIVATION; CASCADE; POTENT;
D O I：
10.1002/ejoc.202001266
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, mild, and efficient oxidative copper-catalyzed regioselective trifluoromethylation of imidazo[1,5-a]-N-heteroarenes have been developed using Langlois(,) (NaSO2CF3) reagent as CF3 source. This method gives biologically relevant trifluoromethylated fused imidazoles in moderate to good yields with good functional group tolerance. The key features of the reaction are mild conditions, short reaction time, and room temperature reaction.
引用
收藏
页码：246 / 252
页数：7
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