Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease

被引：300
|
作者：
Yates, Clara M. [1 ]
Calder, Philip C. [2 ]
Rainger, G. Ed [1 ]
机构：
[1] Univ Birmingham, Sch Clin & Expt Med, Ctr Cardiovasc Sci, Birmingham B15 2TT, W Midlands, England
[2] Univ Southampton, Fac Med, Human Dev & Hlth Acad Unit, Southampton SO16 6YD, Hants, England
来源：
PHARMACOLOGY & THERAPEUTICS | 2014年 / 141卷 / 03期
关键词：
Omega-3 polyunsaturated fatty acid; Eicosapentaenoic acid; Docosahexaenoic acid; Inflammation; Eicosanoid; Resolvin; FISH-OIL SUPPLEMENTATION; TUMOR-NECROSIS-FACTOR; RANDOMIZED CONTROLLED-TRIAL; PROLIFERATOR-ACTIVATED RECEPTORS; CYTOKINE-INDUCED EXPRESSION; EUROPEAN PROSPECTIVE COHORT; PLACEBO-CONTROLLED TRIAL; ALPHA-LINOLENIC ACID; NF-KAPPA-B; DOCOSAHEXAENOIC ACID;
D O I：
10.1016/j.pharmthera.2013.10.010
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Omega-3 (n-3) polyunsaturated fatty acids (n-3 PUFAs) have well documented anti-inflammatory properties, and consequently therapeutic potential in chronic inflammatory diseases. Here we discuss the effects of n-3 PUFAs on various inflammatory pathways and how this leads to alterations in the function of inflammatory cells, most importantly endothelial cells and leukocytes. Strong evidence indicates n-3 PUFAs are beneficial as a dietary supplement in certain diseases such as rheumatoid arthritis; however for other conditions such as asthma, the data are less robust. A clearer understanding of the pharmacology of n-3 PUFAs will help to establish targets to modulate chronic inflammatory diseases. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：272 / 282
页数：11
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