Common Variants in ABI3 Influence Cerebrospinal Fluid Total Tau Levels and Cognitive Decline in Progressive Mild Cognitive Impairment Patients

被引：3
|
作者：
Niu, Li-Dong [1 ]
Yin, Rui [2 ]
Li, Jie-Qiong [1 ]
Cao, Xi-Peng [3 ]
Yu, Jin-Tai [4 ,5 ]
Tan, Lan [1 ]
机构：
[1] Qingdao Univ, Qingdao Municipal Hosp, Dept Neurol, 5 Donghai Middle Rd, Qingdao, Shandong, Peoples R China
[2] Nanchang Univ, Queen Mary Sch, Clin Med, Nanchang, Jiangxi, Peoples R China
[3] Qingdao Univ, Qingdao Municipal Hosp, Clin Res Ctr, Qingdao, Shandong, Peoples R China
[4] Fudan Univ, Huashan Hosp, Shanghai Med Coll, Dept Neurol, Shanghai, Peoples R China
[5] Fudan Univ, Huashan Hosp, Shanghai Med Coll, Inst Neurol, Shanghai, Peoples R China
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2019年 / 70卷 / 01期
基金：
中国国家自然科学基金; 加拿大健康研究院; 美国国家卫生研究院;
关键词：
ABI3; biomarkers; mild cognitive impairment; total tau; variant; ALZHEIMERS-DISEASE;
D O I：
10.3233/JAD-190153
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A potential role for ABI3 gene has been suggested in the risk of Alzheimer's disease (AD), but the detailed mechanism before typical AD onset was unclear. In this study, we investigated the associations of ABI3 common variants with cerebrospinal fluid biomarkers and cognitive function scores among non-demented elderly from the ADNI database. We found that, in the progressive mild cognitive impairment group, rs5978930 was associated with total tau levels and rsl 6947151 was associated with cognitive function scores at baseline and over time, suggesting that ABI3 variants may be associated with cognitive decline and may influence AD onset through tau pathology.
引用
收藏
页码：17 / 23
页数：7
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