Asymmetric Synthesis of Tertiary and Secondary Cyclopropyl Boronates via Cyclopropanation of Enantioenriched Alkenyl Boronic Esters

被引：9

作者：

Gutierrez-Bonet, Alvaro ^{[1
]}

Popov, Stasik ^{[1
]}

Emmert, Marion H. ^{[1
]}

Hughes, Jonathan M. E. ^{[1
]}

Nolting, Andrew F. ^{[1
]}

Ruccolo, Serge ^{[1
]}

Wang, Yunyi ^{[2
]}

机构：

[1] Merck & Co Inc, Merck Res Labs MRL, Proc Res & Dev, Rahway, NJ 07065 USA

[2] Merck & Co Inc, Analyt Res & Dev, Merck Res Labs MRL, West Point, PA 19486 USA

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 19期

关键词：

SIMMONS-SMITH CYCLOPROPANATION; SOLID-STATE STRUCTURE; ENANTIOSELECTIVE HYDROBORATION; DERIVATIVES; PHOSPHATES; REAGENTS; LIGAND;

D O I：

10.1021/acs.orglett.2c01018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cyclopropanation of alkenyl boronates and subsequent derivatization of the boronate handle are a convenient strategy to quickly build molecular complexity and access diverse compounds with a high sp(3) fraction. Herein, we describe the asymmetric cyclopropanation of enantioenriched hydrobenzoin-derived alkenyl boronic esters toward the synthesis of tertiary and secondary cyclopropyl boronates.

引用

页码：3455 / 3460

页数：6

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