FGF9 on the move

被引：4
|
作者：
Spicer, Douglas [1 ]
机构：
[1] Ctr Mol Med, Maine Med Ctr Res Inst, Scarborough, ME 04074 USA
来源：
NATURE GENETICS | 2009年 / 41卷 / 03期
关键词：
HEPARAN-SULFATE; MUTATIONS; DYSPLASIA; BINDING;
D O I：
10.1038/ng0309-272
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
FGF receptors have been implicated in a number of syndromes that involve skeletal disorders. A new study in mice has identified a spontaneous mutation in Fgf9 with reduced activity but increased diffusion through tissues, resulting in a gain-of-function phenotype comparable to those due to activating mutations in genes encoding FGF receptors.
引用
收藏
页码：272 / 273
页数：2
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