Synthesis of optically active N-hydroxylamines by asymmetric hydrogenation of nitrones with iridium catalysts

被引：16

作者：

Murahashi, SI ^{[1
]}

Tsuji, T ^{[1
]}

Ito, S ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Engn Sci, Dept Chem, Osaka 5608531, Japan

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 05期

关键词：

D O I：

10.1039/a909927l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Asymmetric hydrogenation of nitrones with the iridium catalyst system, prepared from [IrCl(cod)](2), (S)-BINAP, and (NBu4BH4)-B-n, gives the corresponding N-hydroxylamines, which are important as biologically active compounds and precursors of amines, with high enantioselectivity (up to 86% ee).

引用

页码：409 / 410

页数：2

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