Drug delivery to brain via the blood-brain barrier

被引:114
|
作者
Scherrmann, JM
机构
[1] Hop Fernand Widal, INSERM, U26, F-75475 Paris 10, France
[2] Dept Pharmacocinet, Fac Pharm, F-75270 Paris, France
关键词
blood-brain barrier; brain delivery; carrier-mediated; transcytosis; vector;
D O I
10.1016/S1537-1891(02)00202-1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. Many neurodegenerative diseases, cancer and infections of the brain become more prevalent as populations become older. Despite major advances in neuroscience, the blood-brain barrier (BBB) ensures that many potential therapeutic cannot reach the central nervous system (CNS). The BBB is formed by the complex tight junctions between the endothelial cells of the brain capillaries and their low endocytic activity. This results in the capillary wall that behaves as a continuous lipid bilayer and prevents the passage of polar and lipid-insoluble substances. It is, therefore, the major obstacle to drugs that may combat diseases affecting the CNS. 2. Several strategies for delivering drugs to the CNS have been developed. These enhance the capacity of therapeutic molecules to cross the BBB by modifying the drug itself, or by coupling it to a vector for receptor-mediated or adsorption-mediated transcytosis. 3. The current challenge is to develop drug-delivery systems that ensure that drugs cross the BBB in a safe and effective manner. This review focuses on the strategies developed to enhance drug delivery across the BBB. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:349 / 354
页数:6
相关论文
共 50 条
  • [1] Drug delivery via the blood-brain barrier
    Edwards, RH
    [J]. NATURE NEUROSCIENCE, 2001, 4 (03) : 221 - 222
  • [2] The blood-brain barrier and brain drug delivery
    Koziara, J. M.
    Lockman, P. R.
    Allen, D. D.
    Mumper, R. J.
    [J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2006, 6 (9-10) : 2712 - 2735
  • [3] The Blood-Brain Barrier and Drug Delivery
    Olbricht, William
    [J]. CHEMICAL ENGINEERING PROGRESS, 2013, 109 (03) : 31 - 34
  • [4] Modulation of the Blood-Brain Barrier for Drug Delivery to Brain
    Han, Liang
    [J]. PHARMACEUTICS, 2021, 13 (12)
  • [5] CSF, blood-brain barrier, and brain drug delivery
    Pardridge, William M.
    [J]. EXPERT OPINION ON DRUG DELIVERY, 2016, 13 (07) : 963 - 975
  • [6] Advanced Blood-Brain Barrier Drug Delivery
    Pardridge, William M.
    [J]. PHARMACEUTICS, 2023, 15 (01)
  • [7] Drug Delivery across the Blood-Brain Barrier
    Khawli, Leslie A.
    Prabhu, Saileta
    [J]. MOLECULAR PHARMACEUTICS, 2013, 10 (05) : 1471 - 1472
  • [8] Drug delivery across the blood-brain barrier
    Hartz, AMS
    Bauer, B
    Baehr, CH
    Miller, DS
    Fricker, G
    [J]. CURRENT NANOSCIENCE, 2005, 1 (03) : 203 - 209
  • [9] Breaching the Blood-Brain Barrier for Drug Delivery
    Bell, Robert D.
    Ehlers, Michael D.
    [J]. NEURON, 2014, 81 (01) : 1 - 3
  • [10] Drug delivery through the blood-brain barrier
    Tamai, I
    Tsuji, A
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 1996, 19 (03) : 401 - 424