Pyrimidinylpyrroloquinolones as highly potent and selective PDE5 inhibitors for treatment of erectile dysfunction

被引：22

作者：

Sui, ZH ^{[1
]}

Guan, JH ^{[1
]}

Macielag, MJ ^{[1
]}

Jiang, WQ ^{[1
]}

Zhang, SY ^{[1
]}

Qiu, YH ^{[1
]}

Kraft, P ^{[1
]}

Bhattacharjee, S ^{[1
]}

John, TM ^{[1
]}

Haynes-Johnson, D ^{[1
]}

Clancy, J ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev, Drug Discovery, Raritan, NJ 08869 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2002年 / 45卷 / 19期

关键词：

D O I：

10.1021/jm025545d

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-pyrimidinylpyrroloquinolones were discovered as extremely potent and selective PDE5 inhibitors. Representative compounds demonstrated in vivo efficacy in dog erectile dysfunction models and are orally bioavailable.

引用

页码：4094 / 4096

页数：3

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