Direct Cobalt-Catalyzed Conjugate Addition of Functionalized Aryl Halides and Triflates: A New Strategy for the Conjugate Addition onto Methyl Vinyl Ketone

被引：18

作者：

Amatore, Muriel ^{[1
]}

Gosmini, Corinne ^{[1
]}

机构：

[1] Ecole Polytech, Lab Heteroelements & Coordinat, CNRS, F-91128 Palaiseau, France

来源：

SYNLETT | 2009年 / 07期

关键词：

aryl halides; catalysis; cobalt; direct conjugate addition; methyl vinyl ketone; CROSS-COUPLING REACTIONS; BOND-FORMING REACTIONS; GRIGNARD-REAGENTS; SAMARIUM(II) IODIDE; OXIDATIVE ADDITION; ORGANIC HALIDES; ALKYL-HALIDES; PALLADIUM(0) COMPLEXES; ACTIVATED OLEFINS; PHENYL IODIDE;

D O I：

10.1055/s-0028-1088117

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient cobalt-catalyzed method for the direct con jugate addition of functionalized aryl halides or triflates onto methyl vinyl ketone is described. The experimentally simple procedure relies on the use of a catalytic system consisting of CoBr2(Bpy) and zinc and does not require the preformation of a stoichiometric organometallic species. The approach described herein displays considerable functional-group compatibility at good to excellent yields.

引用

页码：1073 / 1076

页数：4

共 34 条

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ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
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[10] Iron-Catalyzed Conjugate Addition of Aryl Iodides onto Activated Alkenes under Air in Water
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