Is mPGES-1 a promising target for pain therapy?

被引：47

作者：

Scholich, Klaus ^{[1
]}

Geisslinger, Gerd ^{[1
]}

机构：

[1] Univ Frankfurt Klinikum, Pharmazentrum Frankfurt, ZAFES, D-60590 Frankfurt, Germany

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2006年 / 27卷 / 08期

关键词：

D O I：

10.1016/j.tips.2006.06.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cyclooxygenase (COX) inhibitors are widely used analgesic and anti-inflammatory drugs. Owing to undesirable effects caused by unselective COX inhibitors and selective COX-2 inhibitors, microsomal prostaglandin E-2 synthase-1 has been considered as an alternative target for the development of analgesic drugs. However, recent findings question the usefulness of this terminal synthase as a promising drug target for pain therapy.

引用

页码：399 / 401

页数：3

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