Microangiopathy in Naifold Videocapillaroscopy and Its Relations to sE- Selectin, Endothelin-1, and hsCRP as Putative Endothelium Dysfunction Markers among Adolescents with Raynaud's Phenomenon

被引：6

作者：

Gorski, Stanislaw ^{[1
]}

Bartnicka, Marta ^{[2
]}

Citko, Anna ^{[3
]}

Zelazowska-Rutkowska, Beata ^{[4
]}

Jablonski, Konrad ^{[1
]}

Gorska, Anna ^{[2
,5
]}

机构：

[1] Jagiellonian Univ, Dept Med Educ, Med Coll, PL-31530 Krakow, Poland

[2] Med Univ Bialystok, Dept Family Med, PL-15054 Bialystok, Poland

[3] Med Univ Bialystok, Bialystok Childrens Clin Hosp L Zamenhof, Outpatient Clin, PL-15274 Bialystok, Poland

[4] Med Univ Bialystok, Dept Pediat Lab Diagnost, PL-15276 Bialystok, Poland

[5] Med Univ Bialystok, Dept Pediat Rheumatol Immunol & Metab Bone Dis, Rheumatol Outpatient Clin, PL-15276 Bialystok, Poland

来源：

JOURNAL OF CLINICAL MEDICINE | 2019年 / 8卷 / 05期

关键词：

Raynaud's phenomenon; videocapillaroscopy; biomarkers; lipid profile; endothelin dysfunction; children; adolescents; atherosclerosis; C-REACTIVE PROTEIN; CHILDHOOD RHEUMATIC-DISEASES; SOLUBLE ADHESION MOLECULES; NAILFOLD CAPILLAROSCOPY; SYSTEMIC-SCLEROSIS; SUBCLINICAL ATHEROSCLEROSIS; MICROVASCULAR CHANGES; CARDIOVASCULAR RISK; SERUM-LEVELS; DAMAGE;

D O I：

10.3390/jcm8050567

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to analyze the relationship between the qualitative abnormalities on nailfold videocapillaroscopy (NVC), and the concentrations of selected biomarkers (sE-selectin, endothelin-1, high-sensitivity c-reactive protein (hsCRP)) and lipid metabolism parameters in children and adolescents with Raynaud's phenomenon (RP). Raynaud's phenomenon, to assess whether nailfold capillary changes may reflect the degree of systemic blood vessel abnormalities. The study group included 66 patients (34 undifferentiateduRP and 32 secondarysRP) aged 6-19 years and the control group. In both groups, NVC was performed and the selected biomarkers were measured (sE-selectin, endothelin-1, hsCRP) and lipid profile. Endothelin-1, sE-selectin and hsCRP concentrations in patients from both RP groups were significantly higher; concentration of HDL fraction was significantly lower compared with the control group. The analysis of multiple linear regression demonstrated that megacapillaries most strongly determine the sE-selectin value (p = 0.04) and hsCRP (p = 0.03). Both the total cholesterol and low-density lipoprotein (LDL) fraction concentrations were determined by the presence of avascular areas (p = 0.02). In conclusion, specific pathologic NVC changes were associated with higher endothelial damage biomarkers concentration and adverse changes in the lipid profile.

引用

页数：17