Bio-Functionalized Tapered Multimode Fiber Coated With Dengue Virus NS1 Glycoprotein for Label Free Detection of Anti-Dengue Virus NS1 IgG Antibody

被引：14
|
作者：
Mustapa, Mohd Azmir [1 ]
Abu Bakar, Muhammad Hafiz [1 ]
Kamil, Yasmin Mustapha [1 ]
Syahir, Amir [2 ]
Mahdi, Mohd Adzir [1 ]
机构：
[1] Univ Putra Malaysia, Fac Engn, Wireless & Photon Networks Res Ctr, Serdang 43400, Malaysia
[2] Univ Putra Malaysia, Fac Biotechnol & Biomol Sci, Dept Biochem, Serdang 43400, Malaysia
来源：
IEEE SENSORS JOURNAL | 2018年 / 18卷 / 10期
关键词：
Anti-Dengue virus NS1 IgG antibody; dengue virus NS1 glycoprotein; tapered multimode fiber; IMMOBILIZATION; IMMUNOSENSOR; SENSOR; APTES;
D O I：
10.1109/JSEN.2018.2813385
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
This proposed paper demonstrates the development of a bio-functionalized tapered multimode optical fiber for the detection of anti-Dengue virus NS1 Immunoglobin G (IgG). The tapered fiber with waist diameter and waist length of 10 mu m and 10 mm, respectively, promotes the penetration of light modes to the core-cladding interface, creating evanescent wave that are sensitive to changes on the fiber surface. As the fiber is bio-functionalized with Dengue virus (DENV) NS1 glycoprotein specific to anti-DENV NS1 IgG antibodies, alteration on the surface is selective towards the presence of IgG antibodies. The absorbance-based sensor obtained a sensitivity value of 7 x 10-6 a.u/pg/mL with a detection time under 2 min. This paper shows great potential for real-world deployment which impact may bring Dengue diagnostics a step further.
引用
收藏
页码：4066 / 4072
页数：7
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