FRMD3 gene: its role in diabetic kidney disease. A narrative review

被引：12

作者：

Buffon, Marjorie Piuco ^{[1
,2
,3
]}

Sortica, Denise Alves ^{[1
,2
,3
]}

Gerchman, Fernando ^{[1
,2
,3
]}

Crispim, Daisy ^{[1
,2
]}

Canani, Luis Henrique ^{[1
,2
,3
]}

机构：

[1] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Div Endocrine, BR-90035003 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Endocrinol, BR-90035003 Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande do Sul, BR-90035003 Porto Alegre, RS, Brazil

来源：

DIABETOLOGY & METABOLIC SYNDROME | 2015年 / 7卷

关键词：

GENOME-WIDE ASSOCIATION; FERM DOMAIN; PROTEIN; 4.1; NEPHROPATHY; MEMBRANE; FAMILY; SUSCEPTIBILITY; METAANALYSIS; RISK; MICROALBUMINURIA;

D O I：

10.1186/s13098-015-0114-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus, which is considered a worldwide epidemic. Several studies have been developed in order to elucidate possible genetic factors involved in this disease. The FRMD3 gene, a strong candidate selected from genome wide association studies (GWAS), encodes the structural protein 4.1O involved in maintaining cell shape and integrity. Some single nucleotide polymorphisms (SNPs) located in FRMD3 have been associated with DKD in different ethnicities. However, despite these findings, the matter is still controversial. The aim of this narrative review is to summarize the evidence regarding the role of FRMD3 in DKD.

引用

页数：10

共 50 条

[1] FRMD3 gene: its role in diabetic kidney disease. A narrative review
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[2] rs1888747 polymorphism in the FRMD3 gene, gene and protein expression: role in diabetic kidney disease
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[3] rs1888747 polymorphism in the FRMD3 gene, gene and protein expression: role in diabetic kidney disease
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[10] FRMD3 AND ITS ROLE AS A REGULATOR OF TGF-B1-INDUCED RENAL FIBROSIS
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