Maternal, placental and fetal exposure to bisphenol A in women with and without preeclampsia

被引：47

作者：

Leclerc, Francois ^{[1
]}

Dubois, Marie-France ^{[2
]}

Aris, Aziz ^{[1
]}

机构：

[1] Univ Sherbrooke, CHUS, Fac Med & Hlth Sci, Dept Obstet & Gynecol, Sherbrooke, PQ J1H 5N4, Canada

[2] Univ Sherbrooke, CHUS, Fac Med & Hlth Sci, Dept Community Hlth Sci, Sherbrooke, PQ J1H 5N4, Canada

来源：

HYPERTENSION IN PREGNANCY | 2014年 / 33卷 / 03期

关键词：

Bisphenol A; Fetal blood; Maternal blood; Placenta; Preeclampsia; TROPHOBLAST DEPORTATION; ERR-GAMMA; PATHOGENESIS; EXPRESSION; PREGNANCIES; APOPTOSIS; TISSUE; CELLS; SERUM;

D O I：

10.3109/10641955.2014.892607

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objectives: We aimed to investigate potential association between the exposure of bisphenol A (BPA) and preeclampsia. Methods: Concentrations of BPA were assessed in 58 pregnancies including 35 normotensive and 23 preeclamptic women, using a highly sensitive gas chromatography-mass spectrometry (GC-MS) method. Results: BPA was detected in maternal blood, fetal blood and placental tissue; and actual concentrations of BPA were determined. Interestingly, significant accumulation of BPA in the placentas of women with preeclampsia compared to normotensive women has been shown. Conclusions: This is the first study to highlight a significant correlation between preeclampsia and a high accumulation of BPA in the placenta.

引用

页码：341 / 348

页数：8

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