IL-23R Polymorphisms in Patients with Ankylosing Spondylitis in Korea

被引：40

作者：

Sung, Il-Hoon ^{[2
]}

Kim, Tae-Hwan ^{[1
,2
]}

Bang, So-Young ^{[2
]}

Kim, Tae-Jong

Lee, Bitnara ^{[2
]}

Peddle, Lynette ^{[3
]}

Rahman, Proton ^{[3
]}

Greenwood, Celia M. T. ^{[4
]}

Hu, Pingzhao ^{[4
]}

Inman, Robert D. ^{[5
,6
]}

机构：

[1] Hanyang Univ, Hosp Rheumat Dis, Seoul 133792, South Korea

[2] Hanyang Univ, Coll Med, Seoul 133791, South Korea

[3] Mem Univ Newfoundland, Dept Publ Hlth Sci, St John, NF, Canada

[4] Hosp Sick Children, Res Inst, Program Genet & Genome Biol, Toronto, ON M5G 1X8, Canada

[5] Univ Toronto, Toronto, ON, Canada

[6] Toronto Western Hosp, Toronto, ON M5T 2S8, Canada

来源：

JOURNAL OF RHEUMATOLOGY | 2009年 / 36卷 / 05期

关键词：

IL23R; GENOME-WIDE ASSOCIATION; GENETIC-SUSCEPTIBILITY; IL23R; INTERLEUKIN-1; VARIANTS;

D O I：

10.3899/jrheum.081121

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. IL23R polymorphisms have been shown to have a significant association with ankylosing spondylitis (AS). To date, these Studies have been restricted to Caucasian patients with AS. Our Study addresses this relationship in Korean patients with AS. Methods. A total of 451 patients with AS and 392 ethnically matched healthy controls were enrolled. All patients were native Koreans with AS satisfying the modified New York criteria. In total, 10 single nucleotide polymorphisms (SNP) within the IL-23R gene cluster were genotyped. Results. No IL-23R SNP were found to be associated with AS in Koreans. Conclusion. The association of IL23R and AS that is seen in Caucasian patients with AS is not present in Korean patients with AS. (First Release April 15 2009; Rheumatol 2009;36:1003-5; doi: 10.3899/jrheum.081121)

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页码：1003 / 1005

页数：3

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