Two cases of frontal dementia with non specific histological lesions: Nosology clinicopathological discussion

We report two cases of ''frontal lobe dementia'', patho-anatomically defined by non-specific as neuronal loss, gliosis and spongosis. The review of the litterature permitt to discuss the clinical picture of ''fronto-temporal dementia'' in regard to neuropathological basis. Further the boundaries with Pick's disease, Kraepelin disease, subcortical gliosis and the ''prions disaeses'' are considered. Without more precise nosological status, tacking in count the great variability of the clinical signs, we can concluded that, at present time, the term of frontal type dementia with ''non-specific histological features'', that underlines the neuropathological caracteristics is the most appropriate to define this clinico-pathological entity.