Bridging the gaps in 18F PET tracer development

被引：63

作者：

Campbell, Michael G. ^{[1
,8
]}

Mercier, Joel ^{[2
]}

Genicot, Christophe ^{[2
]}

Gouverneur, Veronique ^{[3
]}

Hooker, Jacob M. ^{[4
,5
,6
]}

Ritter, Tobias ^{[1
,4
,7
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

[2] UCB Biopharma SPRL, UCB NewMed, Global Chem, B-1420 Braine Lalleud, Belgium

[3] Univ Oxford, Chem Res Lab, 12 Mansfield Rd, Oxford OX1 3TA, England

[4] Massachusetts Gen Hosp, Div Nucl Med & Mol Imaging, Dept Radiol, Boston, MA 02114 USA

[5] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

[6] Harvard Med Sch, Charlestown, MA 02129 USA

[7] Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany

[8] Barnard Coll, Dept Chem, 3009 Broadway, New York, NY 10027 USA

来源：

NATURE CHEMISTRY | 2017年 / 9卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

FLUORINATION; CATALYSIS; ARENES;

D O I：

10.1038/nchem.2693

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

As compared to the drug discovery process, the development of new 18F PET tracers lacks a well-established pipeline that advances compounds from academic research to candidacy for (pre)clinical imaging. In order to bridge the gaps between methodological advances and clinical success, we must rethink the development process from training to implementation.

引用

页码：1 / 3

页数：3

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