Dupilumab, a fully human anti-hIL4Rα mAb: Efficacy evaluation in a novel murine model with human IL-4 and IL4Rα gene replacements

被引：0
|
作者：
Wang, L. [1 ]
Liu, X. [1 ]
Zhang, W. [1 ]
Tang, Y. [1 ]
Luo, F. [1 ]
Huang, T. [1 ]
Lin, C. [1 ]
Martin, J. [1 ]
Valenzuela, D. [1 ]
Papadopoulos, N. [1 ]
Graham, N. [1 ]
Murphy, A. [1 ]
机构：
[1] Regeneron, Tarrytown, NY USA
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2014年 / 134卷
关键词：
D O I：
暂无
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
066
引用
收藏
页码：S12 / S12
页数：1
相关论文
共 50 条
  • [1] A Fully Human IL4Rα Antibody for Inhibition of IL-4/IL-13-driven Th2 Responses in Allergic Disease
    Kostic, Ana
    Zhang, Wen
    Dore, Anthony
    Coopey, Blerta
    MacDonald, Douglas
    Fury, Wen
    Lin, Calvin
    Hamilton, Jennifer
    Classon, Brendan
    Papadopoulos, Nicholas J.
    Murphy, Andrew
    CLINICAL IMMUNOLOGY, 2010, 135 : S105 - S106
  • [2] EXPRESSION OF IL4 RECEPTORS (IL4R) AND RESPONSE TO IL4 TREATMENT BY HUMAN MELANOMAS AND CARCINOMAS
    HOON, DSB
    MORISAKI, T
    YUZUKI, D
    HAYASHIDA, M
    MORTON, DL
    FASEB JOURNAL, 1992, 6 (04): : A1406 - A1406
  • [3] IL4Rα and IL13Rα1 Are Involved in the Development of Human Gallbladder Cancer
    Ahn, Sung Woo
    Lee, Chang Min
    Kang, Mi-Ae
    Hussein, Usama Khamis
    Park, Ho Sung
    Ahn, Ae-Ri
    Yu, Hee Chul
    Yang, Jae Do
    Yang, Yung-Hun
    Park, Kyungmoon
    Lee, Jongsung
    Jang, Kyu Yun
    Park, See-Hyoung
    JOURNAL OF PERSONALIZED MEDICINE, 2022, 12 (02):
  • [4] Murine IL-4 is able to signal via chimeric human IL-4Rα/mouse γ-chain receptor
    Myburgh, Elmarie
    Horsnell, William G. C.
    Cutler, Antony J.
    Arendse, Berenice
    Kubo, Masato
    Brombacher, Frank
    MOLECULAR IMMUNOLOGY, 2008, 45 (05) : 1327 - 1336
  • [5] Response Of Il-4 And Il-4r Of Human Skeletal Muscle To Strength Training
    Prokopchuk, Olga
    Liu, Yuefei
    Wirth, Klaus
    Schmidtbleicher, Dietmar
    Steinacker, Juergen
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2005, 37 : S241 - S241
  • [6] INDUCTION OF IGE SYNTHESIS BY HUMAN RECOMBINANT (R) IL-4
    JABARA, HH
    GEHA, RS
    VERCELLI, D
    FASEB JOURNAL, 1988, 2 (05): : A1441 - A1441
  • [7] EXPRESSION OF INTERLEUKIN-4 (IL-4) AND INTERLEUKIN-4 RECEPTOR (IL-4R) IN HUMAN KIDNEY
    FURUSU, A
    MIYAZAKI, M
    ABE, K
    TANAKA, S
    OZONO, Y
    HARA, K
    HARADA, T
    KOJI, T
    NAKANE, PK
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1995, 6 (03): : 865 - 865
  • [8] Identification and Characterization of a Novel IL-4 Receptor α Chain (IL-4Rα) Antagonist to Inhibit IL-4 Signalling
    Ahmed, Nayyar
    Dhanapala, Pathum
    Suphioglu, Cenk
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2015, 36 (03) : 831 - 842
  • [9] Lack of association of type 1 diabetes with the IL4R gene
    H. Q. Qu
    M. C. Tessier
    R. Fréchette
    F. Bacot
    C. Polychronakos
    Diabetologia, 2006, 49 : 958 - 961
  • [10] The establishment of humanized IL-4/IL-4RA mouse model by gene editing and efficacy evaluation
    Yan, Peili
    Su, Youhong
    Shang, Chengzhang
    Zhou, Xiaofei
    Yang, Yi
    An, Wenqian
    An, Wenlin
    Yu, Changyuan
    Wang, Shihui
    IMMUNOBIOLOGY, 2020, 225 (05)
12345