Norovirus infection in immunocompromised hosts

被引：92

作者：

Green, K. Y. ^{[1
]}

机构：

[1] NIAID, Caliciviruses Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2014年 / 20卷 / 08期

关键词：

Acquired immunodeficiency; chronic infection; immunocompromised; immunosuppressed; norovirus; HEMATOPOIETIC STEM-CELL; RENAL-TRANSPLANT RECIPIENTS; MURINE NOROVIRUS; FELINE CALICIVIRUS; UNITED-STATES; NOSOCOMIAL TRANSMISSION; ACUTE GASTROENTERITIS; PEDIATRIC-PATIENTS; IN-VIVO; EVOLUTION;

D O I：

10.1111/1469-0691.12761

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Acute gastroenteritis caused by noroviruses often has a duration of 2-3 days and is characteristically self-limiting. In contrast, chronic infection caused by noroviruses in immunocompromised individuals can last from weeks to years, making clinical management difficult. The mechanisms by which noroviruses establish persistent infection, and the role of immunocompromised hosts as a reservoir for noroviruses in the general human population, are not known. However, study of this patient cohort may lead to new insights into norovirus biology and approaches to treatment.

引用

页码：717 / 723

页数：7

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