High hopes for CB2 receptors in neurogenesis

被引:7
|
作者
Downer, Eric J. [1 ]
机构
[1] Natl Univ Ireland Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland
关键词
cannabinoid; CB2 cannabinoid receptor; neural stem cells; neurogenesis; HIV-1; CANNABINOID RECEPTORS; CELL-PROLIFERATION; TRANSGENIC MICE; PHARMACOLOGY;
D O I
10.1111/bph.12548
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
During life, new neurons are continually added to hippocampal circuitry, with evidence suggesting that these adult-born neurons are functionally linked to cognition and emotion. The mammalian brain contains actively dividing neural stem cells in discrete regions, including the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus. Once mature, these neurons integrate into neuronal networks, forming synaptic connections with interneurons, mossy cells and CA3 pyramidal cells Linked ArticleThis article is a commentary on Avraham etal., pp. 468-479 of volume 171 issue 2. To view this paper visit
引用
收藏
页码:1345 / 1346
页数:2
相关论文
共 50 条
  • [1] CB2 receptors in reproduction
    Maccarrone, M.
    BRITISH JOURNAL OF PHARMACOLOGY, 2008, 153 (02) : 189 - 198
  • [2] Neuroprotective effects of CB2 receptors
    Fernandez-Ruiz, J.
    Pazos, M. P.
    Garcia-Arencibia, M.
    Garcia, C.
    Sagredo, O.
    Ramos, J. A.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2008, 18 : S171 - S171
  • [3] A Central Move for CB2 Receptors
    Quraishi, Salma A.
    Paladini, Carlos A.
    NEURON, 2016, 90 (04) : 670 - 671
  • [4] Pharmacology of cannabinoid CB1 and CB2 receptors
    Pertwee, RG
    PHARMACOLOGY & THERAPEUTICS, 1997, 74 (02) : 129 - 180
  • [5] Cannabinoid CB2 Receptors in Health and Disease
    Patel, K. D.
    Davison, J. S.
    Pittman, Q. J.
    Sharkey, K. A.
    CURRENT MEDICINAL CHEMISTRY, 2010, 17 (14) : 1394 - 1410
  • [6] CB2 cannabinoid receptors:: new vistas
    Mackie, K.
    Ross, R. A.
    BRITISH JOURNAL OF PHARMACOLOGY, 2008, 153 (02) : 177 - 178
  • [7] Activation of CB2 Receptors by (-)-Cannabichromene but Not (+)-Cannabichromene
    Udoh, Michael
    Santiago, Marina
    Haneef, Syed
    Rodger, Alison
    Marlowe, Charles K.
    Barr, Philip J.
    Connor, Mark
    CANNABIS AND CANNABINOID RESEARCH, 2025, 10 (01) : e94 - e101
  • [8] Hippocampal Cb2 receptors: an untold story
    Visvanathar, Robin
    Papanikolaou, Maria
    Noga, Diana Aline
    Padua-Reis, Marina
    Tort, Adriano Bretanha Lopes
    Blunder, Martina
    REVIEWS IN THE NEUROSCIENCES, 2022, 33 (04) : 413 - 426
  • [9] Anterior segment CB1 and CB2 cannabinoid receptors
    Song, ZH
    Jiang, J
    Hemesath, A
    McCloud, C
    Zhong, L
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2002, 43 : U1157 - U1157
  • [10] Cannabinoid CB2 receptors in human brain inflammation
    Benito, C.
    Tolon, R. M.
    Pazos, M. R.
    Nunez, E.
    Castillo, A. I.
    Romero, J.
    BRITISH JOURNAL OF PHARMACOLOGY, 2008, 153 (02) : 277 - 285