Effects of L-carnosine on renal sympathetic nerve activity and DOCA-salt hypertension in rats

被引：45
|
作者：
Niijima, A
Okui, T
Matsumura, Y
Yamano, T
Tsuruoka, N
Kiso, Y
Nagai, K
机构：
[1] Niigata Univ, Sch Med, Niigata 9518510, Japan
[2] Osaka Univ Pharmaceut Sci, Dept Pharmacol, Takatsuki, Osaka 5691094, Japan
[3] Osaka Univ, Div Prot Metab, Inst Prot Res, Suita, Osaka 5650871, Japan
[4] Suntory Ltd, Inst Hlth Care Sci, Osaka 6180012, Japan
来源：
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2002年 / 97卷 / 02期
关键词：
blood pressure; hypertension; autonomic nervous system; efferent; leptin;
D O I：
10.1016/S1566-0702(02)00048-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of L-carnosine (beta-alanyl-L-histidine) on the neural activity of the renal sympathetic nerve and on DOCA-salt hypertension in rats were examined. Intravenous injection of 1 mug L-carnosine inhibited renal sympathetic nerve activity in urethane-anesthetized animals, and a diet containing 0.0001% or 0.001% L-carnosine decreased blood pressure elevation in DOCA-salt hypertensive rats. Since L-carnosine is mainly synthesized in the skeletal muscles of mammals, it is not unreasonable to postulate that L-carnosine is an endogenous factor controlling the blood pressure in a manner possibly antagonistic to the obesity-associated hypertensive effect of leptin. (C) 2002 Elsevier Science B.V All rights reserved.
引用
收藏
页码：99 / 102
页数：4
相关论文
共 50 条
  • [1] Sympathetic nerve activity during development of DOCA-salt hypertension
    Yemane, Henok T.
    Burris, Sarah K.
    Knuepfer, Mark M.
    [J]. FASEB JOURNAL, 2009, 23
  • [2] SUPPRESSION OF RENAL SYMPATHETIC ACTIVITY WITH POTASSIUM SUPPLEMENT IN DOCA-SALT RATS
    SATO, Y
    FUJITA, T
    [J]. JAPANESE HEART JOURNAL, 1984, 25 (02): : 253 - 261
  • [3] Effects of L-carnosine on splenic sympathetic nerve activity and tumor proliferation
    Horii, Yuko
    Shen, Jiao
    Fujisaki, Yoshiyuki
    Yoshida, Kokichi
    Nagai, Katsuya
    [J]. NEUROSCIENCE LETTERS, 2012, 510 (01) : 1 - 5
  • [4] Superoxide independent effects of tempol on blood pressure and sympathetic nerve activity in DOCA-salt hypertensive rats
    Xu, H
    Fink, GD
    Galligan, JJ
    [J]. HYPERTENSION, 2003, 42 (03) : 398 - 398
  • [5] Sympathetic activation in the development of DOCA-salt hypertension
    Kandlikar, Sachin
    King, Andrew J.
    Novotny, Martin
    Fink, Gregory
    [J]. FASEB JOURNAL, 2008, 22
  • [6] Mild DOCA-salt hypertension: sympathetic system and role of renal nerves
    Kandlikar, Sachin S.
    Fink, Gregory D.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2011, 300 (05): : H1781 - H1787
  • [7] IMPORTANCE OF RENAL SYMPATHETIC TONE IN THE DEVELOPMENT OF DOCA-SALT HYPERTENSION IN THE RAT
    KATHOLI, RE
    NAFTILAN, AJ
    OPARIL, S
    [J]. HYPERTENSION, 1980, 2 (03) : 266 - 273
  • [8] RETARDATION OF THE DEVELOPMENT OF HYPERTENSION IN DOCA-SALT RATS BY RENAL DENERVATION
    TAKAHASHI, H
    IYODA, I
    YAMASAKI, H
    TAKEDA, K
    OKAJIMA, H
    SASAKI, S
    YOSHIMURA, M
    NAKAGAWA, M
    IJICHI, H
    [J]. JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1984, 48 (06): : 567 - 574
  • [9] Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in DOCA-salt rats
    Xu, H
    Fink, GD
    Galligan, JJ
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2002, 283 (03): : H885 - H892
  • [10] Hypertension Precedes Changes in Afferent Renal Nerve Activity and Renal Dysfunction in DOCA-Salt Rat Model
    Parvin, Irin
    Gauthier, Madeline
    Dennis, Melissa R.
    Morales, Mark
    Banek, Christopher T.
    [J]. FASEB JOURNAL, 2022, 36
12345