Comparison of renal lesions in cats and dogs using pathomorphological and immunohistochemical methods

被引：6

作者：

Kutlu, Tuncer ^{[1
]}

Alcigir, Gunay ^{[2
]}

机构：

[1] Hatay Mustafa Kemal Univ, Dept Pathol, Fac Vet Med, Antakya, Turkey

[2] Ankara Univ, Dept Pathol, Fac Vet Med, Ankara, Turkey

来源：

BIOTECHNIC & HISTOCHEMISTRY | 2019年 / 94卷 / 02期

关键词：

Chronic disease; epithelial-mesenchymal transformation; fibrosis; kidney; nephritis; nephrosis; EPITHELIAL-MYOFIBROBLAST TRANSDIFFERENTIATION; PROGRESSIVE TUBULOINTERSTITIAL FIBROSIS; MESENCHYMAL TRANSITION EMT; NESTIN EXPRESSION; TUBULAR CELLS; KIDNEY; VIMENTIN; FAILURE; IDENTIFICATION; INJURY;

D O I：

10.1080/10520295.2018.1522670

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We investigated the pathogenesis of chronic renal fibrosis in cats and dogs using immunohistochemistry. We used the avidin-biotin complex peroxidase (ABC-P) method with antibodies against transforming growth factor-beta 1, cytokeratin, E-cadherin, S100A4, alpha-smooth muscle actin, vimentin and nestin to determine whether tubule epithelial cells had undergone epithelial-mesenchymal transformation (EMT) that resulted in loss of epithelial cells and an increased number of mesenchymal cells. Although nephrosis was more common in dogs, nephritis was more common in cats; these pathologies developed in both kidneys. We found that EMT participated in the pathogenesis of renal fibrosis in both dogs and cats.

引用

页码：126 / 133

页数：8

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