Three-Component Coupling Reaction Triggered by Insertion of Arynes into the S=O Bond of DMSO

被引：147
|
作者：
Liu, Feng-Lei [1 ]
Chen, Jia-Rong [1 ]
Zou, You-Quan [1 ]
Wei, Qiang [1 ]
Xiao, Wen-Jing [1 ,2 ]
机构：
[1] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China
[2] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 30072, Peoples R China
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 14期
基金：
美国国家科学基金会;
关键词：
MULTICOMPONENT REACTIONS; STRAIGHTFORWARD SYNTHESIS; VINYLOGOUS AMIDES; N-HETEROAROMATICS; TERMINAL ALKYNES; QUINONE METHIDES; ACCESS; ISOCYANIDES; CHEMISTRY; HETEROANNULATION;
D O I：
10.1021/ol501638x
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unprecedented three-component coupling reaction of arynes, alpha-bromo carbonyl compounds, and DMSO triggered by insertion of arynes into the S=O bond of DMSO has been developed. The reaction can generate a wide range of multisubstituted aryl methyl thioethers in good yields, wherein DMSO serves as both methylthiolation reagent and oxygen source.
引用
收藏
页码：3768 / 3771
页数：4
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