CyanoFactory, a European consortium to develop technologies needed to advance cyanobacteria as chassis for production of chemicals and fuels

被引：23

作者：

Lindblad, Peter ^{[1
]}

Fuente, David ^{[13
]}

Borbe, Friederike ^{[15
]}

Cicchi, Bernardo ^{[20
]}

Conejero, J. Alberto ^{[14
]}

Couto, Narciso ^{[9
]}

Celesnik, Helena ^{[8
]}

Diano, Marcello M. ^{[19
]}

Dolinar, Marko ^{[8
]}

Esposito, Serena ^{[19
]}

Evans, Caroline ^{[9
]}

Ferreira, Eunice A. ^{[3
,4
,6
]}

Keller, Joseph ^{[7
]}

Khanna, Namita ^{[1
]}

Kind, Gabriel ^{[2
]}

Landels, Andrew ^{[9
,10
]}

Lemus, Lenin ^{[13
]}

Noirel, Josselin ^{[12
]}

Ocklenburg, Sarah ^{[15
]}

Oliveira, Paulo ^{[3
,4
]}

Pacheco, Catarina C. ^{[3
,4
]}

Parker, Jennifer L. ^{[9
]}

Pereira, Jose ^{[3
,4
]}

Khoa Pham, T. ^{[9
]}

Pinto, Filipe ^{[3
,4
]}

Rexroth, Sascha ^{[7
]}

Roegner, Matthias ^{[7
]}

Schmitz, Hans-Juergen ^{[15
]}

Silva Benavides, Ana Margarita ^{[17
,18
]}

Siurana, Maria ^{[14
]}

Tamagnini, Paula ^{[3
,4
,5
]}

Touloupakis, Eleftherios ^{[16
]}

Torzillo, Giuseppe ^{[20
]}

Urchueguia, Javier F. ^{[13
]}

Wegelius, Adam ^{[1
]}

Wiegand, Katrin ^{[7
]}

Wright, Phillip C. ^{[9
,11
]}

Wutschel, Mathias ^{[15
]}

Wuenschiers, Roebbe ^{[2
]}

机构：

[1] Uppsala Univ, Dept Chem Angstrom, Microbial Chem, Box 523, SE-75120 Uppsala, Sweden

[2] Univ Appl Sci, Biotechnol & Chem, Technikumpl 17, DE-09648 Mittweida, Germany

[3] Univ Porto, i3S, Porto, Portugal

[4] Univ Porto, IBMC, Porto, Portugal

[5] Univ Porto, Dept Biol, Fac Ciencias, Porto, Portugal

[6] Univ Porto, ICBAS, Porto, Portugal

[7] Ruhr Univ Bochum, Fac Biol & Biotechnol, Plant Biochem, D-44780 Bochum, Germany

[8] Univ Ljubljana, Fac Chem & Chem Technol, Vecna Pot 113, SI-1000 Ljubljana, Slovenia

[9] Univ Sheffield, Dept Chem & Biol Engn, ChELSI Inst, Sheffield, S Yorkshire, England

[10] Plymouth Marine Lab, Prospect Pl, Plymouth PL1 3DH, Devon, England

[11] Newcastle Univ, Fac Sci Agr & Engn, Fac Off, Sch Chem Engn & Adv Mat, Newcastle, NSW NE1 7RU, Australia

[12] Conservatoire Natl Arts & Metiers, LGBA, F-75003 Paris, France

[13] Univ Politecn Valencia, Inst Aplicac Tecnol Informac & Comunicac Avanzada, Valencia, Spain

[14] Univ Politecn Valencia, Inst Univ Matemat Pura & Aplicada, Valencia, Spain

[15] KSD Innovat GmbH, Werksstr 15, D-45527 Hattingen, Germany

[16] CNR, Ist Ric Ecosistemi Terr, Via Madonna Piano 10, I-50019 Sesto Fiorentino, Italy

[17] Univ Costa Rica, Escuela Biol, San Jose 11501, Costa Rica

[18] Univ Costa Rica, Ctr Invest Ciencias Mar & Limnol CIMAR, San Jose 11501, Costa Rica

[19] Business Innovat Ctr, Sci Ctr, M2M Engn Sas, Via Coroglio, Naples, Italy

[20] CNR, Ist Valorizzaz Legno & Specie Arboree, Via Madonna Piano 10, I-50019 Florence, Italy

来源：

ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS | 2019年 / 41卷

关键词：

Cyanobacterial synthetic biology toolbox; DataWarehouse; Chassis robustness; Biosafety; Improved electron chain; Large-scale photobioreactor cultivation; SP PCC 6803; SYNTHETIC BIOLOGY; HYDROGEN-PRODUCTION; GENE-EXPRESSION; LIGHT-FIELD; SYNECHOCYSTIS; MICROALGAE; CULTURES; GROWTH; DESIGN;

D O I：

10.1016/j.algal.2019.101510

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

CyanoFactory, Design, construction and demonstration of solar biofuel production using novel (photo) synthetic cell factories, was an R&D project developed in response to the European Commission FP7-ENERGY-2012-1 call "Future Emerging Technologies" and the need for significant advances in both new science and technologies to convert solar energy into a fuel. CyanoFactory was an example of "purpose driven" research and development with identified scientific goals and creation of new technologies. The present overview highlights significant outcomes of the project, three years after its successful completion. The scientific progress of CyanoFactory involved: (i) development of a ToolBox for cyanobacterial synthetic biology; (ii) construction of DataWarehouse/Bioinformatics web-based capacities and functions; (iii) improvement of chassis growth, functionality and robustness; (iv) introduction of custom designed genetic constructs into cyanobacteria, (v) improvement of photosynthetic efficiency towards hydrogen production; (vi) biosafety mechanisms; (vii) analyses of the designed cyanobacterial cells to identify bottlenecks with suggestions on further improvements; (viii) metabolic modelling of engineered cells; (ix) development of an efficient laboratory scale photobioreactor unit; and (x) the assembly and experimental performance assessment of a larger (1350 L) outdoor flat panel photobioreactor system during two seasons. CyanoFactory - Custom design and purpose construction of microbial cells for the production of desired products using synthetic biology - aimed to go beyond conventional paths to pursue innovative and high impact goals. CyanoFactory brought together ten leading European partners (universities, research organizations and enterprises) with a common goal - to develop the future technologies in Synthetic biology and Advanced photobioreactors.

引用

页数：15

共 7 条

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PROTEIN & CELL, 2010, 1 (03) : 207 - 210
[2] Engineering cyanobacteria for fuels and chemicals production
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