Transferosomal gel for transdermal delivery of risperidone: Formulation optimization and ex vivo permeation

Among these vesicular carriers, transferosomes are widely investigated and are gaining importance recently due to their ability to overcome the permeation difficulties through the stratum corneum. The objectives of the current investigation were to optimize and evaluate transferosomal transdermal gels containing risperidone. Transferosomes containing risperidone were formulated by reverse-phase evaporation and were transferred to 4% methylcellulose gel. The lipid and surfactant ratios on drug entrapment efficiency (DEE) and ex vivo risperidone permeation flux (Jss) of transferosomal gels through skin were optimized. The optimized formulation showed 61.54 2.14% DEE, 589.50 nm average vesicle diameter and 20.90 mV zeta potential. Jss of optiritzed gel was measured as 0.2387 +/- 0.0245}mu g/cm2/h. This tranferosomal system for transdermal risperidone delivery could be a better alternative over the conventional therapy, (C) 2017 Elsevier B.V. All rights reserved.