Molecular dynamics simulations of ternary lipid bilayers containing plant sterol and glucosylceramide

被引：11

作者：

Emami, Shiva ^{[1
,2
]}

Azadmard-Damirchi, Sodeif ^{[2
]}

Peighambardoust, Seyed Hadi ^{[2
]}

Hesari, Javad ^{[2
]}

Valizadeh, Hadi ^{[3
]}

Faller, Roland ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem Engn, Davis, CA 95616 USA

[2] Univ Tabriz, Dept Food Sci, Coll Agr, Tabriz 5166616471, Iran

[3] Tabriz Univ Med Sci, Dept Pharmaceut, Fac Pharm, Tabriz, Iran

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 2017年 / 203卷

关键词：

Lipid bilayer; Sitosterol; Sphingolipid; Glucosylceramide; Molecular dynamics; PLASMA-MEMBRANES; PHOSPHOLIPID-BILAYERS; BIOLOGICAL-MEMBRANES; OAT ROOT; CHOLESTEROL; PHOSPHATIDYLCHOLINE; PHYTOSTEROLS; DOMAINS; MODEL; PHASE;

D O I：

10.1016/j.chemphyslip.2017.01.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An atomic-level molecular dynamics simulation was carried out to study the effects of a plant sterol (sitosterol) and glucosylceramide (GlcCer) on a 1,2-dilinoleoylposphocholine (DLiPC) membrane. Initially, a membrane containing 50 mol% sitosterol was compared with that containing the same ratio of cholesterol. These simulations showed differential condensing and ordering effects of sitosterol and cholesterol, with cholesterol being slightly more efficient than sitosterol in packing the membrane more tightly to a liquid ordered phase. By incorporation of 9.3% GlcCer on DLiPC/sterol membrane no notable change was observed in terms of area per lipid, bilayer thickness, order parameter and lateral diffusion. Some clusters of GlcCer/sterol were observed at higher ratio of GlcCer (15.5%), supporting the existence of GlcCer/sitosterol-enriched L-o-domains on the nanometer scale in the plant lipid mixture. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：24 / 32

页数：9