Fully automated spectrophotometric method for the determination of buspirone in pharmaceutical preparations

被引：6
|
作者：
Ribeiro, Marta F. T.
Santos, Joao L. M.
Lima, Jose L. F. C.
Dias, Ana C. B.
Zagatto, Elias A. G.
机构：
[1] Univ Porto, Fac Farm, Dept Quim Fis, REQUIMTE, P-4090030 Oporto, Portugal
[2] Univ Sao Paulo, Ctr Engn Nucl & Agr, Piracicaba, Brazil
来源：
ANALYTICAL LETTERS | 2006年 / 39卷 / 11期
关键词：
multipumping flow analysis; spectrophotometry; buspirone; Folin-Ciocalteu reagent;
D O I：
10.1080/00032710600755348
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A fully automated kinetic method for the spectrophotometric determination of buspirone in pharmaceutical preparations is proposed. The analytical system was implemented by using multiple solenoid micropumps for sample and reagents insertion, which led to improved operational simplicity and low reagent consumption. A three-way solenoid valve enabled the establishment of two parallel reactors and the exploitation of the fixed time approach for differential kinetics. Linear calibration plots for buspirone concentrations of up to 60 mgL(-1) were obtained, with a detection limit of 2.8 mgL(-1). The sampling rate was about 55 samples per hour.
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页码：2243 / 2253
页数：11
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