Employing Microbubbles and High-Frequency Time-Resolved Scanning Acoustic Microscopy for Molecular Imaging

被引：0
|
作者：
Anastasiadis, P. [1 ]
Klibanov, A. L. [2 ]
Layman, C. [1 ]
Bost, W. [3 ]
Zinin, P. V. [4 ]
Lemor, R. M. [3 ]
Allen, J. S. [1 ]
机构：
[1] Univ Hawaii Manoa, 2540 Dole St,Holmes Hall 302, Honolulu, HI 96822 USA
[2] Univ Virginia, Cardiovasc Med & Biomed Engn, Charlottesville, VA 22903 USA
[3] Fraunhofer Inst Biomed Technol, St Ingbert, Germany
[4] Univ Hawaii, SOEST, Honolulu, HI 96822 USA
来源：
13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3 | 2009年 / 23卷 / 1-3期
基金：
美国国家卫生研究院;
关键词：
Ultrasound; Ultrasound Contrast Agents; Endothelial Cells; High-Frequency Acoustic Microscopy; Mechanical Cell Properties; MUSCLE-CELLS;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Acoustic microscopy offers unique advantages in the investigation of the mechanical properties of biological materials. Ultrasound contrast agents (microbubbles) provide unique acoustic scattering signatures for novel imaging and, in combination with ligands, facilitate molecular imaging capabilities. The potential role and application of microbubble contrast agents at ultra-high frequencies (> 100 MHz) remains an open question. We examine microbubble contrast agents at 200 MHz, 400 MHz and 1.0 GHz in the vicinity of endothelial cells. Visualization of individual microbubbles is demonstrated at 1.0 GHz.
引用
收藏
页码：746 / +
页数：2
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