CLINICAL CHARACTERISTICS OF THYROID PAPILLARY CARCINOMA PATIENTS WITH CLT AND EFFECT ON LYMPH NODE METASTASIS

Objective: To investigate the clinical characteristics of thyroid papillary carcinoma patients with CLT and effect on lymph node metastasis. Methods: Clinical data of 2,133 thyroid papillary carcinoma patients admitted to our hospital from January 2015 to December 2019 were analyzed retrospectively, including 505 cases with CLT. The clinicopathologic data of thyroid papillary carcinoma patients with and without CLT were compared and logistic regression model was used to analyze the independent influencing factors of lymph node metastasis in thyroid papillary carcinoma patients. Results: 1) The male proportion, age, lymph node metastasis rate and central lymph node me-tastasis rate of thyroid papillary carcinoma patients with CLT were significantly lower than those without CLT (P<0.05). 2) The results of univariate analysis showed that the incidence of lymph node metastasis in patients who were male, aged < 40, with a long diameter of lymph node > 1 cm, multiple lesions, capsule invasion and CLT were significantly higher than that of other subgroups (P<0.05). Meanwhile, the incidence of >= 6 lymph node metastases in patients who were male, aged < 40, with a long diameter of lymph node > 1cm, multiple lesions, capsule invasion and CLT were significantly higher than that of other subgroups (P<0.05). 3) Multivariate analysis showed that male, aged <40, long diameter of lymph node >1 cm, multiple lesions and capsule invasion were all independent risk factors for lymph node metastasis and >= 6 lymph node metastases (P<0.05). CLT was the independent protective factor for patients with lymph node metastasis (P<0.05). Conclusion: Most patients with thyroid papillary carcinoma with CLT are female, younger and have lower risks of lymph node and central lymph node metastasis; CLT is an independent protective factor for lymph node metastasis