Metal-Free Cyclopropanol Ring-Opening C(sp3)-C(sp2) Cross-Couplings with Aryl Sulfoxides

被引：25

作者：

Chen, Dengfeng ^{[1
]}

Fu, Yuanyuan ^{[1
]}

Cao, Xiaoji ^{[2
]}

Luo, Jinyue ^{[1
]}

Wang, Fei ^{[1
]}

Huang, Shenlin ^{[1
]}

机构：

[1] Nanjing Forestry Univ, Coll Chem Engn,Jiangsu Prov Key Lab Chem & Utiliz, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat F, Jiangsu Key Lab Biomass Based Green Fuels & Chem, Nanjing 210037, Jiangsu, Peoples R China

[2] Zhejiang Univ Technol, Coll Chem Engn, 18 Chaowang Rd, Hangzhou 310014, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 14期

关键词：

PUMMERER REACTION CHEMISTRY; C-METHYLATED DIHYDROCHALCONES; NUCLEOPHILIC ORTHO-ALLYLATION; BOND-FORMING REACTIONS; DIRECT BETA-ARYLATION; OXIDATIVE CYCLIZATION; INTERRUPTED PUMMERER; ALPHA-ARYLATION; KETONES; PALLADIUM;

D O I：

10.1021/acs.orglett.9b01908

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free method for formal beta-arylation/heteroarylation of ketones through efficient cyclopropanol ring-opening cross-couplings with aryl sulfoxides at room temperature has been developed. This protocol shows a broad substrate scope and promising scalability. In addition, the utility of the beta-arylated ketones is further demonstrated through a variety of postcoupling transformations and synthetic applications.

引用

页码：5600 / 5605

页数：6

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