Convenient regioselective functionalization at the upper-rim of p-tert-buty1calix(18)arene through a protection-deprotection procedure

被引：29

作者：

Gaeta, C ^{[1
]}

Gregoli, L ^{[1
]}

Martino, M ^{[1
]}

Neri, P ^{[1
]}

机构：

[1] Univ Salerno, Dipartimento Chim, I-84081 Baronissi, SA, Italy

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 49期

关键词：

calixarenes; calix[8]arenes; upper-rim functionalization; protection-deprotection;

D O I：

10.1016/S0040-4039(02)02204-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A viable method to obtain calix[8]arenes selectively functionalized at the upper rim of 1,5-aromatic rings is reported. The procedure relies on protected, readily accessible 1,5-xylylene-bridged derivatives, which are easily deprotected by hydrogenolysis. The method allowed the synthesis of the first examples of calix[8]arenes partially substituted with p-nitro, p-amino, quinone and hydroquinone functionalities. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：8875 / 8878

页数：4