Synthesis, Crystal Structure and Antitumor Activity of 4-(5-(2,6-Difluorophenyl)-1,3,4-oxadiazol-2-ylthio)-2-(trifluoromethyl)thieno[2,3-d]pyrimidine

被引：0
|
作者：
Song Xin-Jian [1 ,2 ]
Li Chen-Chen [1 ]
Wang Xu-Mei [1 ]
Sun Qi [1 ]
Yang Ping [1 ]
机构：
[1] Hubei Univ Nationalities, Sch Chem & Environm Engn, Enshi 445000, Peoples R China
[2] Sichuan Univ Sci & Engn, Coll Chem & Environm Engn, Zigong 643000, Peoples R China
来源：
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2019年 / 38卷 / 08期
基金：
中国国家自然科学基金;
关键词：
thieno[2,3-d]pyrimidine; 1,3,4-oxadiazole; fluorinated compound; crystal structure; antitumor activity; FACILE SYNTHESIS; DERIVATIVES;
D O I：
10.14102/j.cnki.0254-5861.2011-2437
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The title compound 4-(5-(2,6-difluorophenyl)-1,3,4-oxadiazol-2-ylthio)-2-(trifluoromethyl)thieno[2,3-d]pyrimidine (C15H5F5N4OS2, M-r = 416.35) was designed and synthesized as antitumor agent, and its structure was determined by H-1 NMR, C-13 NMR, MS, elemental analysis and single -crystal X-ray diffraction. The crystal belongs to monoclinic system, space group P21/c with a = 9.904(2), b = 10.057(2), c = 16.595(3) angstrom, beta = 100.000(3)degrees, V = 1627.9(6) angstrom(3), Z = 4, F(000) = 832, D-c = 1.699 g/cm(3), mu = 0.395 mm(-1), R = 0.0468 and wR = 0.1255 for 4726 independent reflections (R-int = 0.0336) and 2847 observed ones (I > 2 sigma(I)). The in vitro antitumor activity of the title compound was preliminarily evaluated by the standard MTT assay.
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页码：1344 / 1348
页数：5
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