Diabetic Retinal and Choroidal Edema in SDT Rats

被引：18
|
作者：
Toyoda, Fumihiko [1 ]
Tanaka, Yoshiaki [1 ]
Shimmura, Machiko [1 ]
Kinoshita, Nozomi [1 ]
Takano, Hiroko [1 ]
Kakehashi, Akihiro [1 ]
机构：
[1] Jichi Med Univ, Saitama Med Ctr, Dept Ophthalmol, Omiya Ku, 1-847 Amanuma Cho, Saitama 3308503, Japan
来源：
JOURNAL OF DIABETES RESEARCH | 2016年 / 2016卷
关键词：
THICKNESS; TYPE-2;
D O I：
10.1155/2016/2345141
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We evaluated the features of diabetic retinal and choroidal edema in Spontaneously Diabetic Torii (SDT) rats. We measured the retinal and choroidal thicknesses in normal Sprague-Dawley (SD) rats (n = 9) and SDT rats (n = 8). The eyes were enucleated 40 weeks later after they were diagnosed with diabetes, and 4-micron sections were cut for conventional histopathologic studies. The mean retinal and choroidal thicknesses were significantly thicker in the SDT rats than in the normal SD rats. The choroidal thickness was correlated strongly with the retinal thickness in both rat models. Diabetic retinopathy (DR) and diabetic choroidopathy appeared as edema in the SDT rats. The retinal thickness was correlated strongly with the choroidal thickness in the SDT rats, which is an ideal animal model of both DR and choroidopathy.
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页数：6
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