Diagnosis of pertussis: a historical review and recent developments

被引：40
|
作者：
Wendelboe, Aaron Mark
Van Rie, Annelies
机构：
[1] Santa Fe, NM 87505
[2] AMW, Santa Fe, NM 87505
[3] Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC
[4] AVR: Department of Epidemiology, 2104H McGavran Greenberg Hall, Chapel Hill
来源：
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2006年 / 6卷 / 06期
关键词：
culture; DFA; epidemiology; paired and single serology; PCR; sensitivity; specificity; symptoms;
D O I：
10.1586/14737159.6.6.857
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The accurate and timely diagnosis of pertussis continues to be challenging. The widespread use of pertussis vaccines has dramatically altered the epidemiology and clinical presentation of pertussis disease, such that many cases do not present with the hallmark symptoms, such as inspiratory whoop, post-tussive vomiting and paroxysmal cough. A variety of laboratory tools are available to aid in the diagnosis of pertussis, including culture, direct fluorescent antibody testing, PCR, and paired and single serology techniques. This article reviews the strengths and limitations, including the sensitivity and specificity of each of these diagnostic tools.
引用
收藏
页码：857 / 864
页数：8
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