Novel titanocene anti-cancer drugs derived from fulvenes and titanium dichloride

被引：97
|
作者：
Tacke, M [1 ]
Allen, LT
Cuffe, L
Gallagher, WM
Ying, L
Mendoza, O
Müller-Bunz, H
Rehmann, FJK
Sweeney, N
机构：
[1] Univ Coll Dublin, CSCB, Conway Inst Biomol & Biomed Res, Dept Chem, Dublin 4, Ireland
[2] Univ Coll Dublin, Dept Pharmacol, Conway Inst Biomol & Biomed Res, Dublin 4, Ireland
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2004年 / 689卷 / 13期
关键词：
anti-cancer drug; cis-platinum; titanocene; fulvene; LLC-PK; A2780/cp70;
D O I：
10.1016/j.jorganchem.2004.04.015
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Starting from 6-(p-N,N-dimethylanilinyl)fulvene (1a) or 6-(pentamethylphenyl)fulvene (1b) [1,2-di(cyclopentadienyl)-1,2di(p-N,N-dimethylaminophenyl)ethanediyl] titanium dichloride (2a) and [1,2-di(cyclopentadienyl)-1,2-bis(pentamethylphenyl)ethanediyl] titanium dichloride (2b) and their corresponding dithiocyanato complexes (3a, 3b) were synthesized. Titanocene 2b did not show a cytotoxic effect, but when 2a was tested against pig kidney carcinoma cells (LLC-PK) or human ovarian carcinoma cells (A2780/cp70) inhibitory concentrations (IC50) of 2.7 x 10(-4) and 1.9 x 10(-4) M, respectively, were observed. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：2242 / 2249
页数：8
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