Mutagenic and cytostatic activities of the Xylopia laevigata essential oil in human lymphocytes

被引：6
|
作者：
Pereira, Tais Susane [1 ]
Machado Esquissato, Giovana Natiele [1 ]
Costa, Emmanoel Vilaca [2 ]
de Lima Nogueira, Paulo Cesar [3 ]
Alves de Castro-Prado, Marialba Avezum [1 ]
机构：
[1] Univ Estadual Maringa, Dept Biotecnol Genet & Biol Celular, Maringa, Parana, Brazil
[2] Univ Fed Amazonas, Dept Quim, Manaus, Amazonas, Brazil
[3] Univ Fed Sergipe, Dept Quim, Sao Cristovao, SE, Brazil
来源：
NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 10期
关键词：
Xylopia laevigata; essential oil; mutagenic activity; chemical composition; cytostasis; COMET ASSAY; GENOTOXICITY; CONSTITUENTS; EXTRACT; LEAVES;
D O I：
10.1080/14786419.2019.1624956
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Hydro-distilled essential oil from leaves of Xylopia laevigata was characterized by GC-MS. Twenty-seven components were identified and the oil's major constituents comprised germacrene D, bicyclogermacrene, (E)-caryophyllene and germacrene B. The cytotoxicity of the essential oil of X. laevigata (EOXL), determined by MTT and mitotic index methods in cultured human lymphocytes was observed in all tested concentrations. Cultures treated with EOXL demonstrated significant increase in the frequencies of micronuclei in the cytokinesis-block micronucleus assay (CBMN) and reduction of the cytokinesis-block proliferation index (CBPI) rates. Results demonstrated the cytostatic and mutagenic effects of EOXL, the latter for the first time.
引用
收藏
页码：1682 / 1685
页数：4
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