The strategies and techniques of drug discovery from natural products

被引：117

作者：

Zhang, Li ^{[1
,2
]}

Song, Junke ^{[1
]}

Kong, Linglei ^{[1
]}

Yuan, Tianyi ^{[1
]}

Li, Wan ^{[1
]}

Zhang, Wen ^{[1
]}

Hou, Biyu ^{[1
]}

Lu, Yang ^{[3
]}

Du, Guanhua ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Drug Target Res & Drug Screening, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Gen Off, Beijing 100050, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Polymorph Drug, Beijing 100050, Peoples R China

来源：

PHARMACOLOGY & THERAPEUTICS | 2020年 / 216卷

关键词：

Drug discovery; Natural product; Strategy; Technique; 3-HYDROXY-3-METHYLGLUTARYL COENZYME; HYPOCHOLESTEROLEMIC AGENT; MONACOLIN-K; INHIBITORS; ML-236A; BIOINFORMATICS; INFORMATICS; CHEMISTRY; MECHANISM; REDUCTASE;

D O I：

10.1016/j.pharmthera.2020.107686

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Natural products have been the main sources of new drugs. The different strategies have been developed to find the new drugs based on natural products. The traditional and ethic medicines have provided information on the therapeutic effects and resulted in some notable drug discovery of natural products. The special activities of the medicine plants such as the side effects have inspired scientists to develop the novel small molecular. The micro organisms and the endogenous active substances from human or animal also become the important approaches to the drug discovery. The tremendous progress in technology led to the new strategies in drug discovery from natural products. The bioinformation and artificial intelligence have facilitated the research and development of natural products. We will provide a scene of strategies and technologies for drug discovery from natural products in this review. (C) 2020 Published by Elsevier Inc.

引用

页数：13

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