Regioselective nucleophilic ring-opening reaction of chiral epoxyallyl alcohols: a ready access to the pyran core of macrolactin 3

被引：10
|
作者：
Krishna, Palakodety Radha [1 ]
Nomula, Rajesh [1 ]
Krishna, Kallaganti V. S. Rama [2 ]
机构：
[1] CSIR Indian Inst Chem Technol, Organ & Biomol Chem Div, Discovery Lab, Hyderabad 500007, Andhra Pradesh, India
[2] CSIR Indian Inst Chem Technol, Ctr Nucl Magnet Resonance, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 22期
关键词：
Macrolactins; Sharpless epoxidation; Regioselective epoxide ring-opening; Oxa-Michael addition; STEREOSELECTIVE TOTAL-SYNTHESIS; NONENOLIDE;
D O I：
10.1016/j.tetlet.2014.04.068
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein we report the synthetic strategy towards the pyran core of macrolactin 3 via Sharpless epoxidation, titanium(IV) mediated regioselective ring-opening reaction of epoxyallyl alcohol/epoxy alcohol and oxa-Michael addition as the key steps. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3381 / 3383
页数：3
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