Evaluation of particle deposition efficiency in the cell exposure system

被引：0

作者：

Fujitani, Yuji ^{[1
]}

Sugaya, Yutaka ^{[1
]}

Furuyama, Akiko ^{[1
]}

Hirano, Seishiro ^{[1
]}

Takami, Akinori ^{[1
]}

Hashiguchi, Masanori ^{[2
]}

机构：

[1] Natl Inst Environm Studies, 16-2 Onogawa, Tsukuba, Ibaraki 3058506, Japan

[2] Keisoku Engn Syst Co Ltd, Chiyoda Ku, Tokyo 1010047, Japan

来源：

29TH SYMPOSIUM ON AEROSOL SCIENCE AND TECHNOLOGY, 2012 | 2012年

关键词：

AEROSOL;

D O I：

暂无

中图分类号：

P4 [大气科学（气象学）];

学科分类号：

0706 ; 070601 ;

摘要：

The air-liquid interface (ALI) in vitro exposure system is one of the ways of in vitro studies to assess the toxicity of particle matters. The determination of deposition efficiency of particles to cells in the ALI in vitro exposure system is required to obtain dose-response relationship. In this study we simulated particle trajectory in the ALI in vitro exposure system and calculated deposition efficiencies for particle sizes between 30 and 300 nm for 5 sizes. Further, we generated mono-disperse polystyrene latex particles and they exposed to transmission electron microscope (TEM) grid in the ALI in vitro exposure system, then we counted number of deposition particles by using TEM, and derived deposition efficiencies. Deposition efficiencies derived from both methods were consistent and our simulation results were validated.

引用

页码：49 / 50

页数：2

共 50 条

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