Manipulations of chloride ion concentration in the organ of corti alter outer hair cell electromotility and cochlear amplification

被引：0

作者：

Zheng, J. ^{[1
]}

Zou, Y. ^{[1
]}

Nuttall, A. L. ^{[1
]}

Santos-Sacchi, J. ^{[1
]}

机构：

[1] Oregon Hlth Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97239 USA

来源：

Auditory Mechanisms: Processes and Models | 2006年

关键词：

D O I：

10.1142/9789812773456_0016

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

There is evidence that intracellular chloride ions modulate prestin function. This study investigated how chloride ions (Cl-) influence cochlear sensitivity and OHC electromotility. Lowering perilymph Cl- concentration greatly reduced the magnitude of basal turn BM motion and the electrically evoked otoacoustic emissions. These effects could be modulated by tributyltin (TBT, a Cl- ionophore). The results indicate that the electrochemical drive for Cl- is important for normal activity of prestin.

引用

页码：107 / 108

页数：2

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