Polymorphism of prion protein gene in Arctic fox (Vulpes lagopus)

被引：5
|
作者：
Wan, Jiayu [1 ]
Bai, Xue [1 ]
Liu, Wensen [1 ]
Xu, Jing [1 ]
Xu, Ming [1 ]
Gao, Hongwei [1 ]
机构：
[1] Acad Mil Med Sci, Inst Mil Vet, Changchun 130062, Peoples R China
来源：
MOLECULAR BIOLOGY REPORTS | 2009年 / 36卷 / 06期
关键词：
Arctic fox; Polymorphism; Prnp; CREUTZFELDT-JAKOB-DISEASE; TRANSMISSIBLE MINK ENCEPHALOPATHY; EXPERIMENTAL-INFECTION; NATURAL SCRAPIE; SHEEP; PRP; SUSCEPTIBILITY; PROPAGATION; VARIANTS;
D O I：
10.1007/s11033-008-9312-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Prion diseases are fatal neurodegenerative disorders of humans and certain other mammals. Prion protein gene (Prnp) is associated with susceptibility and species barrier to prion diseases. No natural and experimental prion diseases have been documented to date in Arctic fox. In the present study, coding region of Prnp from 135 Arctic foxes were cloned and screened for polymorphisms. Our results indicated that the Arctic fox Prnp open reading frame (ORF) contains 771 nucleotides encoding 257 amino acids. Four single nucleotide polymorphisms (SNPs) (G312C, A337G, C541T, and A723G) were identified. SNPs G312C and A723G produced silent mutations, but SNPs A337G and C541T resulted in a M-V change at codon 113 and R-C at codon 181, respectively. The Arctic fox Prnp amino acid sequence was similar to that of the dog (XM 542906). In short, this study provides preliminary information about genotypes of Prnp in Arctic fox.
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页码：1299 / 1303
页数：5
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