Synthesis of pyrazine-phosphonates and -phosphine oxides from 2H-azirines or oximes

被引：82
|
作者：
Palacios, F [1 ]
de Retana, AMO [1 ]
Gil, JI [1 ]
de Munain, RL [1 ]
机构：
[1] Univ Basque Country, Fac Farm, Vitoria 01080, Spain
来源：
ORGANIC LETTERS | 2002年 / 4卷 / 14期
关键词：
D O I：
10.1021/ol0261534
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Tetrasubstituted pyrazines containing two phosphonate groups 2 in positions 2 and 5 and trisubstituted pyrazines containing a phosphonate 5 or a phosphine oxide group 7 in position 2 are obtained by thermal treatment of 2H-azirine-2-phosphonates I and -phosphine oxides 6. These pyrazines can also be prepared from beta-ketoxime tosylates 9 and 10 or from oxime derived from phosphine oxide 11.
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收藏
页码：2405 / 2408
页数：4
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