A pH-sensitive eosin-block copolymer delivers proteins intracellularly

被引：2
|
作者：
Reinhard, Soren [1 ,2 ]
Han, Hesong [1 ,2 ]
Tuma, Jan [3 ]
Roise, Joachim Justad [1 ,2 ]
Li, I-Che [1 ,2 ]
Li, Jie [1 ,2 ]
Lee, Hye Young [3 ]
Murthy, Niren [1 ,2 ]
机构：
[1] Univ Calif Berkeley, Dept Bioengn, 2151 Berkeley Way, Berkeley, CA 94720 USA
[2] Innovat Genom Inst, 2151 Berkeley Way, Berkeley, CA 94720 USA
[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Integrat Physiol, San Antonio, TX 78229 USA
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 91期
关键词：
Acidic conditions - Developing strategy - pH sensitive;
D O I：
10.1039/d0cc05165a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
There is great interest in developing strategies to deliver proteins into the cytoplasm of cells. We report here a PEG-poly-eosin block copolymer (PEG-pEosin) that can encapsulate proteins and release them in active form under mildly acidic conditions. A PEG-pEosin formulation composed of Cre and the endosomolytic protein LLO efficiently performed gene editing in cells and in the brains of mice after an intracranial injection.
引用
收藏
页码：14207 / 14210
页数：4
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