The role of oxidants and vitamin C on neutrophil apoptosis and clearance

被引：10
|
作者：
Vissers, MCM [1 ]
Hampton, MB [1 ]
机构：
[1] Christchurch Sch Med & Hlth Sci, Free Rad Res Grp, Christchurch, New Zealand
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷
关键词：
apoptosis; hydrogen peroxide; neutrophil; phosphatidylserine; vitamin C;
D O I：
10.1042/BST0320499
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have investigated the role of neutrophil oxidants in the surface changes that result in recognition and uptake of neutrophils by macrophages. We have shown that H2O2 produced by stimulated neutrophils is essential for the surface expression of phosphatidylserine. This does not occur in neutrophils from mice with chronic granulomatous disease and may explain the formation of granuloma in this condition. we have also investigated the role of intracellular vitamin C on neutrophil apoptosis. Cells from vitamin C-deficient mice were found to be less likely to undergo both spontaneous and oxidant-induced apoptosis, with eventual necrosis being the most probable outcome.
引用
收藏
页码：499 / 501
页数：3
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