Synthesis of 2-(4-quinazolinyl)ethyl sulfides via addition of thiols to 4-vinylquinazolines

被引：11
|
作者：
Samaritoni, JG
Babbitt, GE
机构：
[1] DowElanco Discovery Research, DowElanco, Indianapolis
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 04期
关键词：
D O I：
10.1002/jhet.5570340429
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reaction of vinyl and isopropenyl Grignard reagents with quinazoline results in addition to the 3,4-imine bond to give the 4-alkenyldihydroquinazolines 4 which are conveniently aromatized with potassium ferricyanide to the 4-alkenylquinazolines 5. Quinazolines 5 undergo addition with thiols under neutral conditions to afford the quinazolinylethyl sulfides 2 in moderate yields.
引用
收藏
页码：1263 / 1266
页数：4
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