Long Non-coding RNAs as Important Biomarkers in Laryngeal Cancer and Other Head and Neck Tumours

被引：80

作者：

Cossu, Alessia Maria ^{[1
]}

Mosca, Laura ^{[2
]}

Zappavigna, Silvia ^{[2
]}

Misso, Gabriella ^{[2
]}

Bocchetti, Marco ^{[2
]}

De Micco, Federica ^{[1
]}

Quagliuolo, Lucio ^{[2
]}

Porcelli, Marina ^{[2
]}

Caraglia, Michele ^{[1
,2
]}

Boccellino, Mariarosaria ^{[2
]}

机构：

[1] Biogem Scarl, Inst Genet Res, Lab Mol & Precis Oncol, I-83031 Ariano Irpino, AV, Italy

[2] Univ Campania Luigi Vanvitelli, Dept Precis Med, I-80100 Naples, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 14期

关键词：

head and neck cancer (HNC); head and neck squamous-cell carcinoma (HNSCC); laryngeal squamous cell carcinoma (LSCC); laryngeal cancer (LC); long ncRNA (1ncRNA); prognostic biomarker; SQUAMOUS-CELL CARCINOMA; PAPILLARY THYROID-CARCINOMA; POOR-PROGNOSIS; PROLIFERATION; EXPRESSION; HOTAIR; EPIDEMIOLOGY; PROGRESSION; METASTASIS; MIGRATION;

D O I：

10.3390/ijms20143444

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Head and neck carcinoma (HNC) is a heterogeneous disease encompassing a variety of tumors according to the origin. Laryngeal cancer (LC) represents one of the most frequent tumors in the head and neck region. Despite clinical studies and advance in treatment, satisfactory curative strategy has not yet been reached. Therefore, there is an urgent need for the identification of specific molecular signatures that better predict the clinical outcomes and markers that serve as suitable therapeutic targets. Long non-coding RNAs (1ncRNA) are reported as important regulators of gene expression and represent an innovative pharmacological application as molecular biomarkers in cancer. The purpose of this review is to discuss the most relevant epigenetic and histological prognostic biomarkers in HNC, with particular focus on LC. We summarize the emerging roles of long non-coding RNAs in HNC and LC development and their possible use in early diagnosis.

引用

页数：21

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